منابع مشابه
Origin of Cancers: Gene-Centric Versus Cell-Centric
The article by Gerlinger and colleagues (Mar. 8 issue) [1] is informative because it confirms what we already know. In the clinics, the genetic approach seems inadequate for us to solve the problem of tumor heterogeneity or reaching our goal of personalized care. However, we contend that the genetic approach is invaluable for our understanding of individual cancers and in our design of personal...
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The immune system of mammalian organisms undergoes alterations that may account for an increased susceptibility to certain infections, autoimmune diseases, or malignancies. Well characterized are age related defect in T cell functions and cell mediated immunity. Although it is well established that the functional properties of T cells decrease with age, its biochemical and molecular nature is...
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A unified theory of cell differentiation, aging, and cancer is discussed. All cells are hypothesized to originate from stem cells. These stem cells mature as they divide and eventually reach a fully differentiated cell, which cannot divide. Aging is caused by the loss of stem cells, either due to cell death or terminal differentiation, and by eventual death of fully differentiated cells. Both l...
متن کاملInvestigation of Stem Cell Aging Throughout the Lifetime and Therapeutic Opportunities
Introduction: Aging is a natural phenomenon that is caused by changes in the cells of the body. Theoretically, aging starts from birth and lasts throughout life. These changes affect the function of the cells. Also, in old tissues, the capacity for homeostasis and tissue repair is decline due to destructive changes in specific tissue stem cells, niche of stem cells and systemic factors that reg...
متن کاملOn the particular vulnerability of face recognition to aging: a review of three hypotheses
Age-related face recognition deficits are characterized by high false alarms to unfamiliar faces, are not as pronounced for other complex stimuli, and are only partially related to general age-related impairments in cognition. This paper reviews some of the underlying processes likely to be implicated in theses deficits by focusing on areas where contradictions abound as a means to highlight av...
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ژورنال
عنوان ژورنال: Frontiers in Bioscience
سال: 2021
ISSN: 1093-9946,1093-4715
DOI: 10.2741/4888